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Characterization and Validation of Two Zebrafish Models of Traumatic Brain Injury (TBI).

Victoria Elizabeth McCutcheon

出版	University of Toronto, 2015
URL	http://books.google.com.hk/books?id=NAzktwEACAAJ&hl=&source=gbs_api

註釋

Traumatic brain injury (TBI) is a leading cause of death and morbidity in industrialized countries. The cost and time associated with pre-clinical development of TBI therapeutics is lengthy and expensive with a poor track record of successful translation to the clinic. The zebrafish is an emerging model organism with unique advantages in amenability to high-throughput automated pre-clinical drug evaluation. We developed a chemical model of TBI in zebrafish larvae as a reliable surrogate for TBI with quantifiable outcome measures for use in high-throughput drug screening. The aim is then for results to be confirmed in our adult model of TBI. We used a targeted high intensity focused ultrasound to produce the first non-penetrating brain injury model in adult zebrafish. Results indicate that the zebrafish exhibits responses to injury and intervention similar to mammalian pathophysiology after TBI and suggest the possibility of using the model to efficiently screen for potential therapeutic candidates.