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Animal Models for the Study of Human Disease
Li Chen
Richard P. Shannon
You-Tang Shen
其他書名
Chapter 8. Animal Models for Cardiovascular Research
出版
Elsevier Inc. Chapters
, 2013-05-29
主題
Medical / General
Science / Life Sciences / Zoology / General
Medical / Laboratory Medicine
Science / Life Sciences / Anatomy & Physiology
Science / Life Sciences / Biology
Science / Life Sciences / General
Medical / Internal Medicine
ISBN
0128071982
9780128071984
URL
http://books.google.com.hk/books?id=NEt1DAAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state with appropriate direct measurements of cardiovascular function, are needed to serve as a better translational bridge between preclinical and clinical studies. In this chapter, we primarily focus on surgically instrumented large animal models of common cardiovascular disease studied in the conscious state. In addition, several important physiological factors that influence the characteristics of the models, as well as the importance of proper data interpretation, will also be discussed.