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High-fat Diet Impact on Intestinal Cholesterol Conversion by the Microbiota and Serum Cholesterol Levels
Alena M. Bubeck
Paul Urbain
Cathrine Horn
Lisa Ferrari
Hannah K. Ruple
Daniel Podlesny
Stefanie Zorn
Johnny Laupsa-Borge
Caroline Jensen
Inge Lindseth
Gülen Arslan Lied
Jutta Dierkes
Gunnar Mellgren
Hartmut Bertz
Silke Matysik
Sabrina Krautbauer
Gerhard Liebisch
Hans-Frieder Schoett
Simon N. Dankel
Florian W. Fricke
出版
Universität
, 2023
URL
http://books.google.com.hk/books?id=NR9Q0AEACAAJ&hl=&source=gbs_api
註釋
Abstract: Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary habits, and serum lipids has not been characterized in detail. We measured conserved proportions of cholesterol high and low-converter types in individuals with and without obesity from two distinct, independent low-carbohydrate high-fat (LCHF) dietary intervention studies. Across both cohorts, cholesterol conversion increased in previous low-converters after LCHF diet and was positively correlated with the fecal relative abundance of Eubacterium coprostanoligenes. Lean cholesterol high-converters had increased serum triacylglycerides and decreased HDL-C levels before LCHF diet and responded to the intervention with increased LDL-C, independently of fat, cholesterol, and saturated fatty acid intake. Our findings identify the cholesterol high-converter type as a microbiome marker, which in metabolically healthy lean individuals is associated with increased LDL-C in response to LCHF