This book is the first evidence-based evaluation of the present limitations and controversies in clear aligner therapy. It discusses problems in software, mechanotherapy, attachment optimization, interceptive treatment, the mandibular advancement appliance, complex movements, interproximal reduction, extraction therapy, deep bite/open bite correction, finishing, and overcorrection. Unlike current available texts on clear aligner therapy, this book features a nonpartisan, critical analysis of the problems of the technique and demonstrates their clinical implications. Unique solutions to the current limitations of clear aligner therapy are presented, and systematic strategies and protocols for addressing a vast range and complexity of malocclusions commonly confronted by practitioners are introduced. The book helps orthodontists, dentists, dental students, dental educators, technicians, and bioengineers to investigate prevailing misconceptions, and to address significant controversies and dilemmas in clear aligner therapy.