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The Acetylator Genes and Drug Response

Wendell W. Weber

出版	Oxford University Press, 1987
主題	Medical / PharmacologyScience / Life Sciences / Genetics & Genomics
ISBN	01950393279780195039320
URL	http://books.google.com.hk/books?id=OThOAQAAIAAJ&hl=&source=gbs_api

註釋

This comprehensive account of hereditary acetylation in humans and animals is based on the premise that varied individual responses to drugs, chemicals, and carcinogens are profoundly influenced by genetic factors. Acetylation, the mechanism by which the body disposes of many chemicals encountered in everyday life, presents a unique example of how a multiplicity of genetically determined differences in drug response can arise from a single metabolic theme, and of how the understanding of a pharmacogenetic trait can be used to prevent human illness of environmental origin. This monograph assesses the role of drug acetylation as a genetic factor capable of altering susceptibility to therapeutic drug effects and toxicity, and provides a unified view of the genetic and biochemical features of acetylation polymorphisms.