返回Google圖書搜尋

Tale of Two Alks

其他書名	Alk1 and Alk5 in Tgf́Îø1-induced Myofibroblast
出版	University of Georgia, 2019
URL	http://books.google.com.hk/books?id=P4LlzQEACAAJ&hl=&source=gbs_api

註釋Because TGFÎø type-1 receptors are the primary mediators in the initiation of myofibroblast differentiation and tissue fibrosis, it appears that which TGFÎø type-1 receptor present in the fibroblasts at a given time will determine the course of myofibroblast development and fibrosis. Literature suggests TGF-Îø type-1 receptors, activin linked kinases 1 and 5 (ALK1 and ALK5) are involved in promoting TGFÎø effects in physiology and pathology. However, the exact TGFÎø type-1 receptor involved in myofibroblast differentiation is still unknown. Our results show that ALK1 is significantly reduced in TGFÎø1 treated fibroblasts with a significant increase in ALK5 expression. Elevated ÎłSMA and Akt pathway in TGFÎø1-induced fibroblasts was reduced after the treatment with ALK5 inhibitor. Our data provides the novel molecular insight on the pathogenesis of myofibroblast differentiation and provides much valuable information to develop suitable drugs to prevent fibrosis by pharmacologically targeting the ALK5 receptor.