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Evaluation of calibration methods for estimation of the plasma glucose concentration from interstitial fluid

其他書名	diploma thesis
出版	A. Jarc, 2002
URL	http://books.google.com.hk/books?id=P4rIOgAACAAJ&hl=&source=gbs_api

註釋Since frequent self-monitoring of the glucose level for type 1 Diabetes Mellitus patients using finger-pricks is associated with pain, inconvenience and risk of infection, through research has been undertaken concerning the development of a continous monitoring system measuring glucose in the interstitial fluid of the subcutaneous tissue. The open-flow microperfusion developed in Graz was used to gain direct access to the interstitial fluid (ISF) and proved its usefulness in the monitoring of the interstitial glucose.Interstitial glucose closely mirrors the plasma glucose concentration.To estimate plasma glucose out of ISF, the iSF glucose is calibrated against the PG concentration. In this thesis defferent calibration methods were proposed and tested with the help of several statistical approaches, so as to find out which method best described the relationship between PG and ISF glucose values. The calibration methods were based on the assumption that there is a linear relationship between G and ISF glucose within the whole glucose range. For the calibration method which most accurately described the relationship between both glucose values, two calibration points lying in different metabolic states of PG with corresponding ISF values were used. Furthermore, an intercept in a linear regression equation of calibration points, with ISF glucose values as an independent variable plotted versus PG values as a dependent variable was not set to zero. These results were further applied in order to formulate detailed instructions for the calibration of online glucose monitoring system.