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Induced Pluripotent Stem Cells in Brain Diseases

Vivi M. HeineStephanie DoovesDwayne HolmesJudith Wagner

其他書名	Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.
出版	Springer Science & Business Media, 2011-11-23
主題	Science / Life Sciences / Developmental BiologyScience / Life Sciences / Cell BiologyMedical / NeurologyMedical / PediatricsScience / Life Sciences / NeuroscienceScience / Life Sciences / Genetics & Genomics
ISBN	94007281669789400728165
URL	http://books.google.com.hk/books?id=PU5iJhFHE9UC&hl=&source=gbs_api
EBook	SAMPLE

註釋Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).