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Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones
Robert Doran
出版Springer, 2015-06-24
主題Science / Chemistry / OrganicScience / Chemistry / Industrial & TechnicalScience / Chemistry / ClinicalScience / Chemistry / Physical & TheoreticalScience / Life Sciences / Biochemistry
ISBN33192054479783319205441
URLhttp://books.google.com.hk/books?id=Pbf-CQAAQBAJ&hl=&source=gbs_api
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註釋This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.