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Myeloid-Derived Suppressor Cells and Cancer
David Escors
James E. Talmadge
Karine Breckpot
Jo A. Van Ginderachter
Grazyna Kochan
出版
Springer
, 2016-03-15
主題
Medical / Immunology
Medical / Oncology / General
Science / Life Sciences / Molecular Biology
Medical / General
Science / Life Sciences / Cell Biology
ISBN
331926821X
9783319268217
URL
http://books.google.com.hk/books?id=Q-e9CwAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.