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European Patent EP1845083 A2 2007-10-17
出版2007
URLhttp://books.google.com.hk/books?id=QSemOQAACAAJ&hl=&source=gbs_api
註釋This invention belongs to the field of pharmaceutical chemistry and relates tonew arylsulfonohydrazides as inhibitors of UDP-N-acetylmuramylČL-alanine ligaze (MurC) and UDP-N-acetylmuramyl-L-alanineČD-glutamate ligaze (MurD), to procedures for their preparation and pharmaceutical preparations containing the same. The enzymes MurC and MurD are the key enzymes involved in the synthesis of bacterial peptidoglycan, so arylsulfonohydrazide inhibitors possess antibacterial activity.