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The Elegant Orchestration of Its Products in Medicine
出版Nova Publishers, 2005
主題Medical / PhysiologyScience / GeneralScience / Life Sciences / BiochemistryScience / Chemistry / Organic
ISBN15945444769781594544477
URLhttp://books.google.com.hk/books?id=RCxbQv88CXAC&hl=&source=gbs_api
EBookSAMPLE
註釋Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IX N. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.