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Aberrant Neurophysiological Signaling Associated with Speech Impairments in Parkinson's Disease

Alex I. WiesmanPeter W. DonhauserClotilde DegrootSabrina DiabShanna KousaieEdward A. FonDenise KleinSylvain Baillet

出版	Nature Publ. Group, 2023
URL	http://books.google.com.hk/books?id=RDlS0AEACAAJ&hl=&source=gbs_api

註釋Difficulty producing intelligible speech is a debilitating symptom of Parkinson's disease (PD). Yet, both the robust evaluation of speech impairments and the identification of the affected brain systems are challenging. Using task-free magnetoencephalography, we examine the spectral and spatial definitions of the functional neuropathology underlying reduced speech quality in patients with PD using a new approach to characterize speech impairments and a novel brain-imaging marker. We found that the interactive scoring of speech impairments in PD (N)=)59) is reliable across non-expert raters, and better related to the hallmark motor and cognitive impairments of PD than automatically-extracted acoustical features. By relating these speech impairment ratings to neurophysiological deviations from healthy adults (N)=)65), we show that articulation impairments in patients with PD are associated with aberrant activity in the left inferior frontal cortex, and that functional connectivity of this region with somatomotor cortices mediates the influence of cognitive decline on speech deficits.