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Non-invasive Quantification of Alveolar Morphometry Measurements in Older Neversmokers

Gregory Paulin (A.)

出版	School of Graduate and Postdoctoral Studies, University of Western Ontario, 2015
URL	http://books.google.com.hk/books?id=RWYCxQEACAAJ&hl=&source=gbs_api

註釋

Diffusion-weighted noble gas pulmonary magnetic resonance imaging (MRI) provides in vivo images with a contrast uniquely sensitive to molecular displacement at cellular and sub-cellular length scales. We estimated the external airway radius (R) and internal airway radius (r) of the alveolar dimensions to evaluate potential differences in acinar duct morphometries in healthy older never-smokers and compared those with a group of exsmokers. The acinar duct and alveolar MRI morphometry results were within the physiologically-valid range of parameters. Estimated values of internal (r) and external (R) airway radius as well as alveolar sheath (h) and mean linear intercept (Lm) for individual subjects were similar with low variance. Results showed that MRI measurements of lung air space size in healthy older never-smokers were elevated compared to previous results reported in younger never-smokers, and lower than in age-matched ex-smokers (p