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Treatment and Survival of Patients with Malignant Ovarian Sex Cord-stromal Cell Tumours: An Analysis of the Arbeitsgemeinschaft Für Gynäkologische Onkologie (AGO) Study Group CORSETT Database

Maximilian KlarHelmut PlettPhilipp HarterFlorian HeitzStefan KommossAndreas Daniel HartkopfMarcel GrubeEva Marielouise RoserJalid SehouliIona BraicuBastian CzogallaAlexander BurgesMichaela BossartMir Fuad HasanovTeresa LinkAnnette StaeblerDoris MayrPaul BuderathAnnette Hasenburg

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=SPQT0AEACAAJ&hl=&source=gbs_api

註釋

Abstract: Background

Malignant sex cord-stromal cell tumours (SCST) account for only 7% of ovarian malignancies. The Arbeitsgemeinschaft fuer Gynaekologische Onkologie (AGO) study group has established a clinicopathological database to provide an overview of the current treatment strategies and survival of SCST patients and to identify research needs.
Methods

Twenty centres provided mixed retro- and prospective data of patients with tumour specimens and second-opinion pathology review treated between 2000 and 2014. Descriptive analyses of treatment strategies, Kaplan-Meier curves and cox regression analyses were conducted.
Results

Two hundred and sixty-two SCST patients were included. One hundred and ninety-one Granulosa-cell tumour (GCT) and 17 Sertoli-Leydig cell tumour (SLCT) patients were stage I disease (>80%). Forty four GCT (18.7%) and two (8.3%) SLCT patients received adjuvant systemic treatment. After a median observation time of 78.2 months, 46% of all SCST patients experienced disease recurrence, treated predominantly with secondary debulking surgery (> 90%). Advanced FIGO stage, lymph node involvement and intra-operative capsule rupture were associated with disease recurrence on univariate analysis (all p 0.05). Median OS time was not reached.brDiscussionbr