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Structure and Function of Glutathione S-Transferases
Kenneth D. Tew
Cecil B. Pickett
Timothy J. Mantle
Bengt Mannervik
出版
CRC Press
, 1993-08-26
主題
Medical / Pharmacology
ISBN
0849345820
9780849345821
URL
http://books.google.com.hk/books?id=TFhDLhmP0uUC&hl=&source=gbs_api
EBook
SAMPLE
註釋
Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.