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Radiation-induced Toxicities and Outcomes After Radiotherapy are Independent of Patient Age in Elderly Salivary Gland Cancer Patients: Results from a Matched-pair Analysis of a Rare Disease

Alexander RühleSofie RothhaarErik HaehlTobias von KalckreuthTetyana SpraveRaluca StoianConstantinos ZamboglouEleni GkikaAndreas KnopfAnca-Ligia GrosuNils Nicolay

出版	Universität, 2021
URL	http://books.google.com.hk/books?id=TPuVzgEACAAJ&hl=&source=gbs_api

註釋

Abstract: Purpose
This study analyzed survival and toxicity after (chemo)radiotherapy for primary salivary gland cancer patients aged ≥ 65 years and compared these results with younger patients using a matched-pair analysis.

Methods
Twenty-nine elderly patients with primary salivary gland carcinomas treated with (chemo)radiotherapy from 2008 to 2020 at University of Freiburg Medical Center were analyzed for oncological outcomes and therapy-associated toxicities. Local/locoregional control (LRC), progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method, and the influence of clinical parameters on patient outcomes was assessed. A matched-pair analysis was performed after matching with patients 65 years.brbrResultsbrNine patients (31.0%) received definitive (chemo)radiotherapy, and 20 patients (69.0%) were treated in the adjuvant setting. 2-year LRC, PFS and OS ranged at 82.4%, 53.7% and 71.8%, respectively. Smoking (HR 3.980, p = 0.020), reduced performance status (HR 3.735, p = 0.016) and higher comorbidity burden (HR 4.601, p = 0.005) correlated with inferior OS. Using a matched-pair analysis with younger patients, elderly patients exhibited a trend towards reduced OS (HR 3.015, p = 0.065), but not PFS (HR 1.474, p = 0.371) or LRC (HR 1.324, p = 0.633). Acute and chronic grade 3 toxicities occurred in 31.0% and 12.5% of elderly patients, respectively, and the matched-pair analysis revealed no significant differences between age groups regarding treatment-related toxicities.brbrConclusion