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Use of Mesenchymal Stem Cells in Pre-Clinical Models of Spinal Cord Injury
Rachel Sarabia Estrada
Alfredo Quinones-Hinojosa
Antonio J. Forte
Paola Suarez Meade
Oluwasen O. Akinduro
Francisco R. Avila Verduzco
Ricardo A. Torres Guzman
Gunel Guliyeva
Hugo Guerrero-Cazares
出版
2018
URL
http://books.google.com.hk/books?id=TToe0AEACAAJ&hl=&source=gbs_api
註釋
Spinal Cord Injury (SCI) is a devastating disease that causes disruption of sensorimotor function below the site of injury. Current management is based on surgical decompression of the neural tissue and pharmacotherapy; however, there is no gold standard treatment readily available for patients in the clinic. This indicates that novel therapeutic strategies for the treatment are still needed in the clinical setting. There are several alternatives that are currently under investigation for the treatment of this disease, with increasing focus in regenerative medicine treatments. Mesenchymal stem cells (MSCs) are one of the most promising candidates for stem cell therapy in SCI, as they are easily obtained, have high safety profiles, and help with neural regeneration in SCI mainly via release of trophic factors, neovascularization, and immunomodulation. In this work, authors provide an insight of the available MSC for neural regeneration, their therapeutic role, and the potential MSC-based therapies for SCI.
