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The Hypotensive Activity of Dihydrocorynantheine, an Alkaloid from Uncaria Callophylla

nee Geh Oo

出版	Organising Committee, 1992
URL	http://books.google.com.hk/books?id=TiVpnQAACAAJ&hl=&source=gbs_api

註釋

The cardiovasxular effects of dihydrocorynantheine were studied in anaesthetised spontaneously hypertensive male rats of weights 230-250 g. Dose-response data showed thatdihydrocorynantheine, at 0.5-5.0 mg/kg i.v., produced immediate falls in the mean arterial pressure by 47.3 + 7.5 - 52.3 + 3.5 mmHg (n=4), and a dose-dependent drop in the heart rate, the highest dose of the alkaloid producing a substantial reduction in the blood pressure and a marked decrease in the heart rate of 42.0 + 3.0 beats/min. In anaesthetised normotensive rats, the hypotensive effect of dihydro-corynantheine was little inhibited by the antimuscarinic drug atropine (2 mg/kg i.v.) nor was it antagonised by the ganglion blocker that hexamethonium (2 mg/kg i.v.).