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Body Mass Index and Atypical Balance Score as Predictors of Treatment Outcomes for Seasonal Affective Disorder
註釋Efficacious treatments for winter seasonal affective disorder (SAD) include light therapy (LT) and cognitive-behavioral therapy (CBT-SAD); however, it is unknown whether patient baseline characteristics differentially predict treatment outcomes. The present study investigated body mass index (BMI) and atypical balance as prognostic and prescriptive predictors of SAD treatment outcomes using data from a parent study in which 177 adults diagnosed with Major Depression, Recurrent with Seasonal Pattern were randomized to either CBT-SAD (n = 88) or LT (n = 89). At pre-treatment, BMI was assessed and atypical balance was derived using the Structured Interview Guide for the Hamilton Rating Scale for Depression--Seasonal Affective Disorder Version (SIGH-SAD). Hierarchical linear and logistic regressions were used to investigate the main effects of treatment type, BMI, and atypical balance score and their interactive effects on SIGH-SAD depression outcomes at post-treatment and first and second winter follow-up. Linear mixed modeling was used to examine the effect of BMI and atypical balance on the rate of SIGH-SAD symptom improvement during the treatment period. BMI x treatment group interaction significantly predicted depression remission at second winter follow-up such that at BMI