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Google圖書搜尋
Ubiquitin Signaling and Autophagy
Paolo Grumati
Ivan Đikić
出版
American Society for Biochemistry and Molecular Biology Publications
, 2017
URL
http://books.google.com.hk/books?id=UrVh0AEACAAJ&hl=&source=gbs_api
註釋
Ubiquitination is a widespread post-translational modification that controls multiple steps in autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of ubiquitin chains are attached as selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent degradation. Moreover, ubiquitin modification of autophagy regulatory components is essential to positively or negatively regulate autophagy flux in both non-selective and selective pathways. We review the current findings that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impact on the development of human diseases.