By examining the dynamic interplay between discourses of fiction and medicine, Novel Medicine demonstrates how fiction incorporated, created, and disseminated medical knowledge in China, beginning in the sixteenth century. Critical readings of fictional and medical texts provide a counterpoint to prevailing narratives that focus only on the “literati” aspects of the novel, showing that these texts were not merely read, but were used by a wide variety of readers for a range of purposes. The intersection of knowledge—fictional and real, elite and vernacular—illuminates the history of reading and daily life and challenges us to rethink the nature of Chinese literature.