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Neurobiology of Cocaine Addiction
Eric J. Nestler
其他書名
A Reprint from "Science and Practice Perspectives"
出版DIANE Publishing, 2008-05
主題Health & Fitness / General
ISBN14289882629781428988262
URLhttp://books.google.com.hk/books?id=Wa5C8vzFRicC&hl=&source=gbs_api
EBookSAMPLE
註釋Cocaine produces its psychoactive & addictive effects primarily by acting on the brain¿s limbic system, a set of interconnected regions that regulate pleasure & motivation. An initial, short-term effect -- a buildup of the neurochemical dopamine -- gives rise to euphoria & a desire to take the drug again. Researchers are seeking to understand how cocaine¿s many longer term effects produce addiction¿s persistent cravings & risk of relapse. This paper focuses on the buildup of the genetic transcription factor DeltaFosB in the limbic system which correlate with addiction-like behaviors in mice & may precipitate very long-lasting changes to nerve cell structure. This is one of the first steps toward an understanding of the transition from cocaine abuse to addiction.