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Subcellular Compartmentalization of Signal Elements and Their Re-distribution in Resting and Activated B Cells

Carolina Alexandra Martinez Grijalva

出版	Georg-August-Universität Göttingen, 2024
URL	http://books.google.com.hk/books?id=WjTq0AEACAAJ&hl=&source=gbs_api

註釋

BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process can lead to immune disorders or B cell malignancies, emphasizing the need to understand this phenomenon. Prior research has mainly focused on individual components of BCR activation, leaving much unexplored. Translocatome studies as innovative techniques based on an unbiased and exploratory approach involving triple SILAC mass spectrometry and LGC offer new insights into re...