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Persistent Bone Impairment Despite Long-term Control of Hyperprolactinemia and Hypogonadism in Men and Women with Prolactinomas

Lukas AndereggenJanine FreyRobert H. AndresMarkus M. LuediHans Rudolf WidmerJürgen BeckLuigi MarianiEmanuel Christ

出版	Universität, 2021
URL	http://books.google.com.hk/books?id=XAJyzgEACAAJ&hl=&source=gbs_api

註釋Abstract: While prolactinoma patients have high bone turnover, current data are inconclusive when it comes to determining whether correction of hyperprolactinemia and associated hypogandism improves osteodensitometric data in men and women over the long term. In a large cohort of including 40 men and 60 women, we studied the long-term impact of prolactinoma treatment on bone mineral density (BMD) in men versus women, assessed adverse effects of a primary surgical or medical approach, and evaluated data for risk factors for impaired BMD at last follow-up using multivariate regression analyses. Median duration of follow-up was 79 months (range 13-408 months). Our data indicate that the prevalence of impaired BMD remained significantly higher in men (37%) than in women (7%, p