Principles of Non-Philosophy is a treatise on the method, axioms and objectives of non-philosophy and represents François Laruelle's mature philosophy.

As well as presenting the method and principles of non-philosophy, it includes a history of the development of non-philosophy, a novel conception of science, a discussion of non-philosophical causality and new theories of the subject and object of thought. Providing an introduction to Laruelle's novel theory of 'non-epistemology' or 'unified theory of thought', this volumes challenges the way we think about the traditional philosophical problems.

Bringing together all the elements of his thought developed over twenty years and laying the foundations for his later work, Principles of Non-Philosophy is arguably Laruelle's magnum opus.