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Peptide-based Drug Design
Michael D. Taylor
其他書名
Controlling Transport and Metabolism
出版Wiley, 1995-04-13
主題Medical / PharmacologyMedical / PharmacyScience / Life Sciences / BotanyScience / Chemistry / Physical & TheoreticalScience / Chemistry / Industrial & Technical
ISBN08412305879780841230583
URLhttp://books.google.com.hk/books?id=YhxtAAAAMAAJ&hl=&source=gbs_api
註釋Provides a framework for designing peptide-based therapeutic agents with improved transport and metabolism properties for optimal in vivo activity. Covers recent advances in molecular biology of transporters as well as what is more classically known about drug metabolism and drug transport of amino acids and peptides. Focuses on intestinal peptide transport, liver peptide transport, peptide delivery to the brain, peptide transport in microorganisms, and approaches to limiting peptide metabolism. Reviews the state of knowledge in the field and provides examples of how knowledge of peptide transport was used to design strategies for improved delivery of specific classes of agents. Details experimental systems that can be used to evaluate transport and metabolism of peptide-based drugs.