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Fourier-transform Infrared Spectroscopic Imaging of Prostate Histopathology

Daniel Celestino Fernandez

出版	University of South Florida, 2003
URL	http://books.google.com.hk/books?id=Z2bLjwEACAAJ&hl=&source=gbs_api

註釋

The successful construction and application of such a model system relies on the ability to compile high-quality spectral database information on a large number of samples with minimal sample-to-sample preparation artifact. Tissue microarrays provide a consistent sample preparation for high-throughput infrared spectroscopic profiling of histologic specimens. Tissue arrays consisting of representative normal healthy prostate tissue as well as pathologic entities including prostatitis, benign prostatic hypertrophy, and prostatic adenocarcinoma were constructed and used as sample populations for infrared spectroscopic imaging at high spatial and spectral resolutions. Histological and pathological features of the imaged tissue were correlated with consecutive tissue sections stained with standard histologic stains and visualized via traditional optical microscopy and reviewed with a trained pathologist.