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Fast Facts: Comprehensive Genomic Profiling
B.L. RapoportG. TronconeF. SchmittS. Nayler
其他書名
Making precision medicine possible
出版Karger Medical and Scientific Publishers, 2020-11-03
主題Medical / Genetics
ISBN33180681959783318068191
URLhttp://books.google.com.hk/books?id=_REIEAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy