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Vpliv nekaterih dejavnikov na hipertrofijo levega prekata pri arterijski hipertenziji brez nočnega znižanja krvnega tlaka

其他書名	doktorska disertacija
出版	M. Jelenc, 2001
URL	http://books.google.com.hk/books?id=_csFOwAACAAJ&hl=&source=gbs_api

註釋Left ventricular hypertrophy is a risk factor for cardiovascular morbidity andmortality in patients with essential hypertension. Insulin resistance and increased sympathetic nervous system activity are also suggested to be risk factors for cardiovascular morbidity. The purpose of the present study was to evaluate the relationship of hyperinsulinemia, insulin resistance, glucose metabolism and sympathetic nervous system activity to left ventricular mass inpatients with essential hypertension in whom blood pressure does not fall during sleep (non-dippers) compared to essential hypertensives with blood pressure fall during sleep (dippers). We would like to find out if they are some differences in glucose and insulin metabolism between the two groups of hypertensives and if hiperinsulinemia or cathecholamines are related to development of left ventricular hypertrophy in the group of non-dippers. Thirthyfour male, non-diabetic out-patients with essential arterial hypertension were included in the studyČ 23 dippers (mean age 44 +- 11 yearsč body mass index 27 +- 3 kgžm2) and 11 non-dippers (mean age 48 +- 11 years, body mass index 27 +- 3 kgžm2). Patients were subdivided in dippers and non-dippers on the basis of 24-hour ambulatory blood pressure monitoring. We measured body weight, height and calculated body mass index. A bidimensional echocardiographic analysis was performed on every enrolled subject. For assessment of left ventricular mass, measurements of posterior wall thickness, interventricular septal thickness and left ventricular internal dimensions were made. Left ventricular mass was calculated according to the formula of Devereux. Left ventricular mass was normalized for body surface andbody height. An oral glucose load of 75 g was administered, and blood samples for plasma glucose and insulin measurements were taken before, and 30,60, and 120 min after the glucose load. (Abstract truncated at 2000 characters).