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High Grade Meningiomas
Andres F. Cardona
Juan Fernando Ramón
Diego Gómez
Fernando Hakim
Enrique Jiménez
Oscar Arrieta
Álvaro Muñoz
Alejandro Ruiz-Patiño
Camila Ordóñez-Reyes
其他書名
Current Therapy Based on Tumor Biology
出版
2018
URL
http://books.google.com.hk/books?id=_h4j0AEACAAJ&hl=&source=gbs_api
註釋
Atypical (WHO grade II) and malignant meningiomas (WHO Grade III) are a rare subset of primary intracranial tumors. Due to the high recurrence rate after surgical resection and radiotherapy, there has been a recent interest in exploring other systemic treatment options for these refractory tumors. Recent advances in molecular sequencing of tumors have elucidated new pathways and drug targets currently being studied. This article provides a thorough overview of novel investigational therapeutics, including targeted therapy, immunotherapy, and new technological modalities for atypical and malignant meningiomas. There is encouraging preclinical evidence regarding the efficacy of the emerging treatments discussed in this chapter. Several clinical trials are currently recruiting patients to translate targeted molecular therapy for recurrent and high-grade meningiomas.