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Chapter 2. Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control
出版Elsevier Inc. Chapters, 2013-08-06
主題Medical / Infectious DiseasesScience / Life Sciences / BiologyScience / Life Sciences / GeneralScience / Life Sciences / Microbiology
ISBN01280602399780128060230
URLhttp://books.google.com.hk/books?id=_xN1DAAAQBAJ&hl=&source=gbs_api
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註釋In humans and mice there exist a multitude of Fcγ receptors (FcγRs) with different affinities and specificities for the different IgG subclasses. Engagement of FcRs on cells usually results in the initiation of an activating or inhibitory signaling cascade that can lead to multiple effector functions, including phagocytosis of opsonized pathogens or immune complexes. In this chapter, we discuss phagocytic cell types and their respective FcγRs that they utilize to phagocytize IgG-coated particles/pathogens. Furthermore, we discuss downstream signaling mechanisms and resulting effects of FcγR-mediated phagocytosis. Special emphasis is given to the role of FcR-mediated phagocytosis in phagocytes for pathogen uptake, subsequent intracellular localization, and pathogen control.