This monograph provides an introduction to the design and analysis of Hybrid High-Order methods for diffusive problems, along with a panel of applications to advanced models in computational mechanics. Hybrid High-Order methods are new-generation numerical methods for partial differential equations with features that set them apart from traditional ones. These include: the support of polytopal meshes, including non-star-shaped elements and hanging nodes; the possibility of having arbitrary approximation orders in any space dimension; an enhanced compliance with the physics; and a reduced computational cost thanks to compact stencil and static condensation.