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Handbook of Polymer Applications in Medicine and Medical Devices
Justin M. SaulDavid F. Williams
其他書名
12. Hydrogels in Regenerative Medicine
出版Elsevier Inc. Chapters, 2013-12-05
主題Technology & Engineering / Engineering (General)Technology & Engineering / Textiles & PolymersTechnology & Engineering / ManufacturingTechnology & Engineering / Materials ScienceMedical / Instruments & Supplies
ISBN01280767479780128076743
URLhttp://books.google.com.hk/books?id=aLlzDAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋Hydrogels are crosslinked polymeric networks containing hydrophilic groups that promote swelling due to interaction with water [1]. While hydrogels are heavily used in the field of regenerative medicine, their application to biomedical systems is not new. In fact, it has been suggested that they were truly the first polymer materials to be developed for use in man [2]. They have been in use for clinical applications since the 1960s, initially for use in ocular applications including contact lenses and intraocular lenses due to their favorable oxygen permeability and lack of irritation leading to inflammation and foreign body response, which was observed with other plastics [3]. Before the concept of tissue engineering and regenerative medicine had gained traction, hydrogels were used for cell encapsulation [4]. They have also been utilized extensively in the clinic for wound healing applications due to their oxygen permeability, high water content, and ability to shield wounds from external agents. Perhaps the largest research focus and utility of hydrogels has been found in their use as controlled release systems. This combination of controlled release and cell encapsulation has led to increasing uses of hydrogels in regenerative medicine applications.