返回Google圖書搜尋

Asymmetric Synthesis of N-allylic Indoles Via Regio- and Enantioselective Allylation of Aryl Hydrazines

出版	Universität, 2015
URL	http://books.google.com.hk/books?id=an-MtQEACAAJ&hl=&source=gbs_api

註釋Abstract: The asymmetric synthesis of N-allylic indoles is important for natural product synthesis and pharmaceutical research. The regio- and enantioselective N-allylation of indoles is a true challenge due to the favourable C3-allylation. We develop here a new strategy to the asymmetric synthesis of N-allylic indoles via rhodium-catalysed N-selective coupling of aryl hydrazines with allenes followed by Fischer indolization. The exclusive N-selectivities and good to excellent enantioselectivities are achieved applying a rhodium(I)/DTBM-Segphos or rhodium(I)/DTBM-Binap catalyst. This method permits the practical synthesis of valuable chiral N-allylated indoles, and avoids the N- or C-selectivity issue