登入選單
返回Google圖書搜尋
Fast Facts: EGFR Exon 20 Insertion Mutations in NSCLC
Julia RotowParneet CheemaPasquale PisapiaGiancarlo Troncone
出版Karger Medical and Scientific Publishers, 2022-06-13
主題Medical / Oncology / GeneralMedical / Clinical Medicine
ISBN33180713669783318071368
URLhttp://books.google.com.hk/books?id=b2Z2EAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋Lung cancer is still a major cause of death globally, but the development of personalized, precision medicine has had a marked effect on treatment management and improved clinical outcomes, particularly for those with advanced stage non-small-cell lung cancer (NSCLC). EGFR mutations are the third most common mutation found in patients with advanced stage NSCLC. First-line treatment with a traditional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is indicated for most patients, but not for patients with EGFR exon 20 insertion mutations (ex20ins). Instead, recent approvals of an EGFR ex20ins-specific TKI (mobocertinib) and a bispecific antibody (amivantamab) targeting both EGFR and mesenchymalepithelial transition factor (MET) offer the potential for improved outcomes in this patient population. Furthermore, new approaches to treatment continue to be developed and trials for new agents with greater activity against ex20ins mutations are ongoing.