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Integration of Signaling Pathways During the Unfolded Protein Response

Sebastian Bernales

出版	University of California, San Francisco, 2006
URL	http://books.google.com.hk/books?id=bBjZpl-92rYC&hl=&source=gbs_api

註釋

We also found that yeast cells expand their ER volume at least 5-fold under UPR-inducing conditions. Surprisingly, we discovered that ER proliferation is accompanied by the formation of autophagosome-like structures that are densely and selectively packed with membrane stacks derived from the UPR-expanded ER. This ER-specific autophagic described utilizes several autophagy genes that are induced by the UPR and are essential for the survival of cells subjected to severe ER stress. Intriguingly, cell survival does not require vacuolar proteases, indicating that ER sequestration into autophagosome-like structures, rather than their degradation, is the important step. Selective ER sequestration may help cells to maintain a new steady-state level of ER abundance even in the face of continuously accumulating unfolded proteins.