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Growth hormone (GH) deficiency in adults

出版	M. Pfeifer, 2001
URL	http://books.google.com.hk/books?id=bCPmNAAACAAJ&hl=&source=gbs_api

註釋Human pituitary secretes growth hormone (GH) throughout the lifespan. In adulthood GH is one of the most important regulators of metabolic processes inthe human bodyČ it enhances lipolysis and lipid oxidation, protein synthesisand sodium and water retention. It regulates body composition and function. Adults who are deficient in GH exhibit a number of abnormal featuresincluding increased adiposity and decreased lean body mass associated with reduced physical fitness. They have increased prevalence of risk factors for atherosclerosisČdyslipidemia, insulin resistance, impaired glucose tolerance, increased fibrinogen, plasminogen activator inhibitor and hypertension. They exhibit increased mortality from cardiovascular, especiallycerebrovascular disease. As GH replacement therapy reduced or abolished most of the risk factors for atherosclerosis in hypopituitary GH deficient adults, it was hypothesised that GH replacement would reverse early functional and morphological signs of atherogenesis. Insulin-tolerance test (ITT) is the Ćgold standardĆ for assessment of GH reserve. In our study three consecutive ITTs were performed in seven normal adult men and two ITTs in 11 men with hypopituitarism ITTs were performed in seven normal adult men and twoITTs in 11 men with hypopituitarism and suspected GH deficiency. We assessed the reproducibility and variability of GH responses. In normal men the within subject peak GH variability was between 5-60%, and the overall variability in 21 tests was 35%. The lowest peak GH concentration was 27 ugžl. All hypopituitary men had severe GH deficiency (all peak GH concentrations