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A New Target for Cancer Prevention and Treatment
出版Karger Medical and Scientific Publishers, 2003-07
主題Medical / ChemotherapyMedical / Clinical MedicineMedical / GastroenterologyMedical / Oncology / GeneralMedical / PharmacologyMedical / Preventive MedicineMedical / Public Health
ISBN33180094079783318009408
URLhttp://books.google.com.hk/books?id=bN43EQAAQBAJ&hl=&source=gbs_api
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註釋Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.