登入選單

返回Google圖書搜尋

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases Fluctuating Asymmetry of Molars in Mice

James Matthew Keller

出版	University of North Carolina at Charlotte, 2005
URL	http://books.google.com.hk/books?id=bxk5nQEACAAJ&hl=&source=gbs_api

註釋

Fluctuating asymmetry (FA), random variation between left and right sides in a bilaterally symmetrical character, is a commonly used measure of developmental instability that is expected to increase with increasing environmental stress. 2,3,7,8-tetrachlorodibenzo p-dioxin (TCDD) is a powerful toxicant and, as such, might be expected to increase developmental instability. In this study, members of the F[subscript]2 generation from an intercross between 2 inbred strains of mice (C57BL/6J and AKR/J) were exposed in utero to TCDD. We hypothesized that TCDD would increase the level of FA in the molars of exposed mice over that of the control mice. In addition, we hypothesized that we would find genes for molar size, shape, or asymmetry that differed in expression in the presence of TCDD. We detected a significant increase in molar shape FA in the TCDD-exposed mice over the control mice although molar size and shape did not differ between these groups. While we did not uncover any genes that acted differently in the TCDD exposed and control groups, we did identify two genes whose epistatic effects on molar size were affected by TCDD.