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From Sequences to Phylodynamics
出版2024
ISBN9798324659998
URLhttp://books.google.com.hk/books?id=c9E40QEACAAJ&hl=&source=gbs_api
註釋"Decoding genomes demonstrates how to uncover information about past evolutionary and population dynamic processes based on genomic samples. The last decades have seen considerable theoretical and methodological advances in this area. These enable the assessment of critical scientific questions such as the impact of environmental changes on biodiversity and the evolution of pathogens during recent epidemics. The book gives the reader a detailed understanding of the whole process: from genome sampling to obtaining biological insights by applying sophisticated statistical and computational analyses. In particular, sequencing of genomic samples, the alignment of sequences, molecular evolution models, phylogenetics, and phylodynamics are core topics. Statistical and computational approaches discussed include dynamic programming, maximum likelihood, Bayesian statistics, and model selection, to name a few. The concepts introduced and applied throughout the book enable readers to answer questions across biological scales, including microevolution, macroevolution, immunology, development, cancer, and epidemiology, as well as in fields other than biology where evolutionary concepts are key, such as linguistics."--Page 4 of cover