Science education is important as it equips students with scientific knowledge that can enrich their everyday lives. It helps students to solve problems, learn to be rational as well as be critical in their thinking. However, science learning is deemed challenging as students see the subject as difficult and sometimes tedious to learn. Thus, interest in science is essential to ensure continuous learning in science. It is important to promote positive attitudes towards science among students. Positive attitudes towards science are associated with better achievement in science, increased cooperation as well as participation in class. Malaysia needs a generation who are creative and critical thinkers, thus it is vital to enhance students’ attitudes towards science. As students spend most of their time in a classroom, therefore, shaping students’ perceptions of science classroom environment is crucial in enhancing their attitudes towards science. This book is adapted and modified from a master’s degree thesis entitled: “Relationship between Form 4 Students’ Perceptions of Science Classroom Environment and Attitudes towards Science” of the first author. This book includes analysis of students’ perceptions of science classroom environment and attitudes towards science. This book attempts to answer questions regarding the level of students’ perceptions of science classroom environment, the level of students’ attitudes towards the effect of gender and school locations on students’ perceptions of science classroom environment and attitudes towards science, and the influence of perceptions of science classroom environment on students’ attitudes towards science. This book will be of interest to researchers in science education, especially, perceptions of science classroom environment and attitudes towards science.