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Autophagy
M.A. Hayat
其他書名
Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volumes 1–4
出版Elsevier Inc. Chapters, 2013-09-03
主題Medical / ImmunologyScience / Life Sciences / Microbiology
ISBN01280692799780128069271
URLhttp://books.google.com.hk/books?id=cotzDAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋Autophagy plays a direct or indirect role in health and disease. A simplified definition of autophagy is that it is an exceedingly complex process which degrades modified, superfluous (surplus) or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. It consists of sequential steps of induction of autophagy, formation of autophagosome precursor, formation of autophagosome, fusion between autophagosome and lysosome, degradation of cargo contents, efflux transportation of degraded products to the cytoplasm, and lysosome reformation. This chapter discusses specific functions of autophagy, the process of autophagy, major types of autophagy, influences on autophagy, and the role of autophagy in disease, immunity, and defense.