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Analysis of Heparanase Expression in Human Natural Killer Cells

Dean Yang Yee

出版	Australian National University, 2010
URL	http://books.google.com.hk/books?id=dJaPAQAACAAJ&hl=&source=gbs_api

註釋

Natural Killer (NK) cells are cells of the innate immune system important for tumour and viral clearance. Lack of functional human NK cells results in severe and recurrent viral infections in humans. Migration of NK cells requires movement through the extracellular matrix (ECM) and basement membrane (BM). The ECM and BM are structural scaffolds which provide shape and support to cells and tissues. Migration to target sites requires the degradation of the ECM and BM. Heparanase (HPSE) is a [beta]3-D-endoglucoronidase which cleaves the heparan sulphate (HS) side chains of heparan sulphate proteoglycans (HSPGs), a major component of the ECM and BM. Expression of HPSE by NK cells may facilitate migration to target sites, and ultimately affect NK function. The expression of HPSE has been documented in several leukocyte cells, but not NK cells. This study investigated whether heparanase is expressed by human NK cells.