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Prices of Orphan Drugs in Four Western European Countries Before and After Market Exclusivity Expiry: a Cross-country Comparison of List Prices and Purchase Prices

Aniek DaneAnne-Sophie Klein GebbinkJan-Dietert BrugmaAlbane Degrassat-ThéasMartin J. HugMorten B. HoulindPascal PaubelPaul-Hugo Marie van der KuyCarin A. Uyl-de Groot

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=e9Rk0AEACAAJ&hl=&source=gbs_api

註釋

Abstract: Background

Increasing pharmaceutical expenditure challenges the sustainability and accessibility of healthcare systems across Europe. Confidentiality restraints hinder assessment of actual prices of Orphan Medicinal Products (OMPs). Hence, we assessed the real prices of brand-name OMPs around market exclusivity expiry (MEE).
Objective

We aimed to explore developments in published list prices (LPs) and confidential hospital purchase prices (PPs) of brand-name OMPs relative to their market exclusivity status in Western European countries with similar GDPs.
Methods

We analyzed LPs and PPs of 13 selected OMPs purchased by university hospitals in Western European countries between 2000 and 2020. For confidentially reasons, proportions were used, with the Dutch LPs of the selected OMPs at the year of MEE serving as reference values. PPs included pre-purchase discounts. Rebates were not considered.
Results

Data were analyzed from hospitals in Denmark (DK) (n = 1), France (FR) (n = 1), Germany (DE) (n = 2), and the Netherlands (NL) (n = 1). Average LPs and PPs of included OMPs dropped gradually but limited over time, with no explicit price drop after MEE. LP levels differed more per country than PP levels: LP range before MEE was 164% (DE)-101% (FR) and after MEE was 135% (DE)-82% (FR); PP range before MEE was 150% (DE)-102% (FR) and after MEE was 107% (DE)-80% (FR). Overall differences between LPs and PPs were 3% in all countries, except for Denmark.brConclusionbr