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Automated Production of Specific T Cells for Treatment of Refractory Viral Infections After Allogeneic Stem Cell Transplantation

Amadeus Tilman HeinzFriso G. J. CalkoenBrigitte StrahmJürgen FinkePeter Lang

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=eDYt0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Therapy-resistant viral reactivations contribute significantly to mortality after hematopoietic stem cell transplantation. Adoptive cellular therapy with virus-specific T cells (VST) has shown efficacy in various single-center trials. However, the scalability of this therapy is hampered by laborious production methods. In this study we describe the in-house production of VST in a closed system (CliniMACS Prodigy® system, Miltenyi Biotec). In addition, we report the efficacy in 26 patients with viral disease following hematopoietic stem cell transplantation in a retrospective analysis (adenovirus, n=7; cytomegalovirus, n=8; Epstein-Barr virus, n=4; multi-viral, n=7). The production of VST was successful in 100% of cases. The safety profile of VST therapy was favorable (n=2 grade 3 and n=1 grade 4 adverse events; all three were reversible). A response was seen in 20 of 26 patients (77%). Responding patients had a significantly better overall survival than patients who did not respond (P