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Effect of Acclimatization of Altitude on Susceptibility of Mice to Influenza A Virus Infection

L. Joe Berry

出版	USAF School of Aviation Medicine, 1955
URL	http://books.google.com.hk/books?id=eU7bGwAACAAJ&hl=&source=gbs_api

註釋

Mice allocated to a simulated altitude of about 20,000 feet for 3 weeks are more resistant to infection with Influenza A virus than (a) normal mice, (b) mice similarly acclimatized but given 3 weeks of recovery at normal pressures prior to infection, and (c) mice made anemic by blood loss, the latter three groups showing no significant differences in susceptibility. Acclimatized mice maintained at altitude for the post-infection period are more resistant than those maintained at atmospheric pressures. These results are attributed to a metabolic disturbance which accompanies acclimatization to altitude and reduces the animal's capacity for virus synthesis.