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A Process for the Preparation of CGMP-phosphodiesterase Inhibitor and Oral Pharmaceutical Formulation Comprising Tadalafil Co-precipitates
Matej Barič (farmacevt.)Primož BenkičSergeja BombekDušan KrašovecVida ŠkrabanjaFranc VrečerPolona BukovecGrega HudovornikVesna Krošelj
其他書名
WO2016012539 (A1)
出版Europäisches Patentamt, 2016
URLhttp://books.google.com.hk/books?id=f6yztAEACAAJ&hl=&source=gbs_api
註釋The present Invention relates to an improved process for preparation of tadalafil and crystallization and/or purification thereof, wherein the processes are conducted at increased pressure. The invention relates also to a process for preparation of tadalafil co-precipitates and to a solid pharmaceutical composition comprising tadalafil co-precipitates and at least one water soluble diluent and/or water insoluble non-swellable diluent, wherein the composition is substantially free of water insoluble swellable diluents.