登入
選單
返回
Google圖書搜尋
The Cerebral Perivascular Cells
Doychin N. Angelov
Michael Walther
Michael Streppel
Orlando Guntinas-Lichius
Wolfram F. Neiss
出版
Springer Science & Business Media
, 2013-03-07
主題
Medical / Neuroscience
Science / Life Sciences / Molecular Biology
Science / Life Sciences / Neuroscience
Medical / General
Science / Life Sciences / Cell Biology
ISBN
3642722512
9783642722516
URL
http://books.google.com.hk/books?id=fQ8fBQAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.