This book profiles 24 athletes who overcame seemingly insurmountable medical odds to attain athletic success. Each profile describes the athlete's problem, the medical issues he or she faced, how success was achieved despite the setback, and the personal qualities that helped the athlete to prevail.

Part I features 15 athletes who dealt with diseases and physical disabilities, including Babe Didrikson Zaharias (cancer), Ron Santo (diabetes), Gail Devers (Graves' disease), Alonzo Mourning (kidney disease), Wilma Rudolph (polio), Scott Hamilton (a pancreatic disorder in childhood) and Jimmy Abbott (born with one hand).

Part II highlights nine athletes who dealt with near-fatal or life-changing accidents and injuries, including Bill Toomey, Three-Finger Brown, Greg LeMond, Lou Brissie and Tommy John.